2.2.1 Communication problems?

Hi,

So I upgraded to 2.2.1 and for the first time EVER I am having USB communications issues. Makerware runs fine for hours talking to the printer, so it is not the hardware etc.
The log file is not very helpful, there is no error... the printer just stops. Sometimes it restarts, other times it does not seem to (have waited 3-5 minutes). The extruder is on and hot, this just burning little molten puddles wherever it is.
When it happens, the log shows a "SENT:" message, with no "READ:" coming back.

Any help will be apprecited.

I didn't find the right solution from the Internet.

References:
forum.simplify3d.com/viewtopic.php?t=2055
Blockchain Application Marketing

Thank you.